Anticancer activity of isolated compounds from twigs of Koelreuteria elegans cultivated in Egypt

Phytochemical constituents have been participated with essential role in the discovery of several clinically effective anticancer agents. The goal this study was to isolate phytoconstituents from Koelreuteria elegans twigs (Sapindacea family) and evaluate their activities against human lung, colon breast carcinoma cell lines. aqueous methanol extract plant's fractionated different solvents preliminary cytotoxicity fractions determined using brine shrimp lethality assay. Nine compounds K. butanol fraction were isolated for first time; gallic acid (1), methyl gallate (2), 6-O- [Galloyl 4- ether]-(α/β)-D-glucopyranose (3), 3, 5-di-O-galloylquinic butyl ester (4), 3,4,5-tri-O-galloylquinic (5), 1,3,4,5-tetra-O-galloylquinic (6), two isomers 3-O-galloyl quinic 4-O-galloyl (7), austrobailignan 1 (8) β-sitosterol (9). structures elucidated spectroscopic techniques. Anticancer fraction, 1were estimated in-vitro by viability results showed significant activity both lines less while almost no lung